Step into the Light

Updated: Mar 18


Photobiomodulation (Red & NIR light therapy)

Step into the light


Introduction

The light bulb was invented in the late 19th century, it was possible to provide light locally to different parts of the body. The vision of laser light in the 1960s made it possible to centralize single-wavelength light and use it for therapeutic applications (LLLT; low-level laser therapy). The new LED light technology has made it possible to replace the soft laser with the most economical LEDs with sufficient luminous efficacy that can narrow the wavelength of light precisely enough.

The link between light and human health has inspired the research in different types of light therapy. Especially within recent years, lightweight devices that emit different wavelengths (colors) of light have been developed. These include red & near-infrared light (NIR) devices that have been noticed to support skin health, wound healing, tissue repair, and even contribute to neural health. This post lists the ways red light & NIR might improve various aspects of health. There are currently over 5000 published research articles on the effect of red light therapy on these effects.

The effects of low-level laser therapy (LLLT) and photobiomodulation are characterized by inverted U-shaped dose-response curves, in which linear responses may be seen only at shallow doses. Whereas linear effects may be negligible, maximal stimulatory effects are typically observed at intermediate doses. However, the linear relationship does not hold at high doses since inhibitory effects are observed instead.

Image: Hormetic effect of photobiomodulation (LLLT; low-level laser therapy).

Source: Rojas, J. & Gonzalez-Lima, F. (2011). Low-level light therapy of the eye and brain. Eye and Brain 3: 49–67.

How does photobiomodulation works?

Red light therapy uses light energy, a form of electromagnetic radiation (EMR). Human cells contain molecules whose functioning can be altered when receiving EMR. Indeed, the uptake of EMR is a necessary process that enables life on Earth. For example, the eye contains photoreceptors that absorb light and contribute to the vision. In addition, some cells contain molecules that are not related to the concept per se but have particular molecules that accept light waves (these are called photoreceptors). In these cells, the light waves cause biological chain reactions that contribute to energy production in the cell.

Photobiomodulation utilizes non-ionizing photonic energy to trigger photochemical changes within cellular structures that are receptive to photons, particularly in mitochondria. Red light and NIR light therapy are believed to mainly work through photo acceptors – the most critical photo acceptor being an enzyme called cytochrome c oxidase.

Red light therapy uses exclusively red- to near-infrared light waves (λ = 600–1100 nm). Red light waves penetrate through the skin and make their way to the cell's mitochondria, increasing the cells' energy production. For example, various events lead to the acceleration of mitochondrial respiration via cytochrome c oxidase. Red light also supports the transcription of new gene products(such as proteins or RNA). Thus, it supports several cellular mechanisms that contribute to healing and cell longevity.

Recently it has been shown that the biochemical effects of photobiomodulation are still present even if the cell does not contain any mitochondria. Although metabolic changes are associated with PBM, CCO is not required for its cell proliferation enhancing effect. Nitric oxide (NO) is involved in a number of the reported light effects on CCO.


This has led the researchers to the possibility that the intrinsic nature of PBM involves the production of nitric oxide. The combination of cytochrome c oxidase and hemoglobin/myoglobin NO display with the photorelease of NO may constitute the heart of PBM.

RED LIGHT VS NEAR-INFRARED LIGHT

Red light's light spectrum is between 630-700 nm. On the other hand, near-infrared wavelengths fall into the invisible part of the light spectrum, being 700-1300 nm. Generally, the longer the wavelength, the deeper the penetration into tissues. Different cell and tissue types have unique light absorption methods at varying wavelengths (other photo acceptors).

Red light and NIR therapy at home

During the first week, use 2 minutes daily. If the device is used for two separate targets (for example, to hand and to foot), the operating time is 1.5 minutes each. If needed, the working time can be increased to 3–5 minutes in the next week and longer if required per target area. Use of more than 15 minutes is not recommended because red light has a narrow therapeutic window – in other words, more prolonged use time does not increase the effect but may even reverse it. People react differently to light, so everyone should test the correct distance from the skin and the duration of use. After initial testing, the device can be used 1-2 times a day, sometimes as little as 2-3 times per week is enough. If you want to reach deeper into the subcutaneous tissue, you can apply it a little longer and shorter distance to the skin (5-10 cm).

The device has light diodes that emit beams classified as red light or near-infrared light (NIR), or both. Depending on the wavelength of the morning, it will penetrate to different depths of the skin surface (NIR penetrates slightly deeper than red light). It's essential to look out for a device that emits wavelengths of light with scientifically supported benefits

  • Red light ≈ 660 nm

  • Infrared light ≈ 850 nm

Image source: Avci, P., Gupta, A., Sadasivam, M., Vecchio, D., Pam, Z., Pam, N., & Hamblin, M. R. (2013). Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery, 32(1), 41–52.

Light therapies and their potential applications

Type of light therapy

Wavelength (nm)

Benefits

Red

600 - 700

Support tissue healing, joint and muscle health, pain reduction, and collagen synthesis

Near-infrared (NIR)

700 - 1300

Generally the same as a red light but goes deeper into tissues, therefore, more helpful in joint, muscle, and pain therapies.

Blue

450-495

Antimicrobial. Used for acne and sun damage

Green (early research)

500 - 580

It might support calmness and reduce migraines

Heliotherapy (sun exposure therapy)

Vary

Support circadian rhythm and vitamin D production. Used for sleep disorders and skin conditions

Bright light therapy

Vary. The most important aspect is the brightness (> 10 000 lux)

Support circadian rhythm. Used for Seasonal Affective Disorder (seasonal depression)


Benefits of red light and near-infrared light therapy

Skin

Red light has been used in cosmetic settings to reduce wrinkles, smoothen the skin and increase skin firmness, as red light can increase collagen production and decrease collagen destruction. Collagen is the connective tissue protein that keeps the skin elastic and wrinkle-free. Collagen production slows down during natural aging, and collagen can be damaged by the sun, toxins, and pollution. Red light is believed to combat the loss of collagen by upregulating epidermal growth factors, lowering skin inflammation, and stimulating various other transport and energy compounds. Together these processes lead to increased skin tissue repair and production.

There are many other ways besides red light to increase collagen production. However, the red light is possibly the safest one. That's because many treatments to the skin require initially damaging the skin surface that then initiates the healing process and collagen production (think derma rolling and chemical peeling). However, these treatments can also lead to adverse side effects such as inflammation. Opposite to this, red light tunnels through the skin, causing a wound-healing reaction without the actual wound. Red light has shown to be a safe and effective option for damaging skin methods, and thus, patient satisfaction rates have been high.

Skin conditions

Some trials conclude that red light can aid in managing skin conditions such as psoriasis, acne, rosacea, Bowen's disease, basal cell carcinoma, and actinic keratosis. It has also been applied to improve wound healing after burns, surgery, and other medical procedures.

An interesting fact for women

During menopause, the lack of estrogen can lead to degeneration of the connective tissue in the vagina and pelvic floor. There is also preliminary evidence that near-infrared light therapy could also be applied to the treatment of vaginal tissues. However, the results are incomplete, and the area warrants more research.

Hair

A review study concluded that red light treatment to the scalp can stimulate hair growth and prevent hair loss in both men and women. Most likely, the light stimulates the epidermal stem cells in the hair follicle bulge. This shifts the hair follicle into the active growth phase (anagen phase), which can lengthen the natural cycle of hair growth.

Pain and tension

Some studies show that near-infrared light might lower pain. For example, one study demonstrated that 830 nm infrared light to temporal muscles (34 seconds) decreased self-reported tension headache pain in women by 60 %. Additionally, their serotonin (the happy hormone) levels were significantly increased three days after the treatment.

In another study, near-infrared light therapy decreased self-reported pain (measured by the WHO criteria) in patients receiving chemotherapy.

A systematic review concluded that near-infrared light therapy and possibly red-light therapy seem to offer short-term pain relief from the tennis elbow.

Red light to support the brain and the eyes

Red light and near-infrared light have been shown to enhance brain and eye functions. Cells in the nervous system, such as in the brain, consume a lot of energy (even 20 % of the body's total energy expenditure). This means that functions such as memory, planning, emotional processing, and motor behavior are very dependent on well-functioning mitochondria and aerobic respiration.

It's been shown that, and near-infrared light treatment to the neural cells (e.g., when applied transcranially) can equally enhance the mitochondrial functioning in the nervous system (via cytochrome c oxidase). Interestingly, animal studies also demonstrated that red light might improve other processes such as neurotransmission, gene expression, and cell longevity (reducing oxidative stress and neuroinflammation).

Like the brain, retinal cells are also highly vulnerable to oxidative damage. Many eye disorders (such as glaucoma and macular degeneration) are associated with mitochondrial dysfunction. Low-level light therapy (red & NIR)might improve optic nerve function and retinal protection.

Photobiomodulation for athletes

Photobiomodulation may also aid elite athletes: it has beneficial effects on mass muscle gain and lowers inflammation and oxidative stress in the muscles. Due to the promising results in athletic performance, researchers have even discussed whether photobiomodulation should be permitted in athletic competitions.

Another potential benefit is support for sleep. Sleep has an integral role in athletic recovery and performance. In one study, whole-body red-light treatment in the evening for 14-days improved sleep, melatonin levels, and endurance performance of elite athletes.

Red light and weight loss

Studies show that red light therapy may help to tone the body and reduce body fat. In one study, adult men and women who did not change their diet lost on average 2.15 cm around their waist (the treated area) after 4 weeks of red light treatment. In another study, morning red and green light exposure significantly reduced the levels of ghrelin - a hormone that increases the feeling of hunger. Other studies also support the use of red light for body contouring.

The recommended duration depends on the parameters of the device. These include:

Wavelength (nm, nanometers)

Distance between wave peaks. The most effective red and near-infrared light wavelengths are 600-1100 nm.

Exposure time

Time used for exposing skin to the light

Fraction

The total dose is divided into different treatment sessions (fractions) separated by specific intervals (minutes, hours, days)

Contact type

Shallow, non-contact or contact

Power (W, watts)

Amount of energy flowing through the device in a second (J/s).

Irradiance (W/cm2) /

power density /

Light intensity

Power per surface area

Interestingly, it seems that photobiomodulation with red and near-infrared light can have a systemic effect even if a small patch of skin is exposed to the light. For example, one study noticed that red light reduced inflammation systemically, even when the treatment was targeted only to the lower back.

Summary

  • There are over 9000 research articles on the benefits of red and near-infrared light (NIR) photobiomodulation on human health.

  • Red light and near-infrared light treatment can improve tissue health, skin health, muscle recovery, and neural health.

  • Devices are easy to use and safe to do at home. However, the user needs to carefully read the instructions and parameters of the light to avoid overdoing it.

  • Red and NIR work via light energy, which improves cellular energy production via a cytochrome C oxidase enzyme.

  • There are many different light devices on the market, some more effective than others.

  • Try photobiomodulation, for example, to improve and firm the skin, reduce wrinkles, improve athletic performance, upregulate energy, or support weight loss.


If you have any questions please call 805-705-1691


Enlightened Wellness

21 E Carrillo St Suite 150

Santa Barbara, CA 93101


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